Article
Plasma concentrations of afamin are associated with the prevalence and development of metabolic syndrome.
Circulation. Cardiovascular genetics - 1 Dec 2014
Kronenberg Florian, Kollerits Barbara, Kiechl Stefan, Lamina Claudia, Kedenko Lyudmyla, Meisinger Christa, Willeit Johann, Huth Cornelia, Wietzorrek Georg, Altmann Maria E, Thorand Barbara, Melmer Andreas, Dähnhardt Doreen, Santer Peter, Rathmann Wolfgang, Paulweber Bernhard, Koenig Wolfgang, Peters Annette, Adham Ibrahim M, Dieplinger Hans
Abstract excerpt
BACKGROUND: Afamin is a human plasma vitamin E-binding glycoprotein primarily expressed in the liver and secreted into the bloodstream. Because little is known about (patho)-physiological functions of afamin, we decided to identify phenotypes associated with afamin by investigating transgenic mice overexpressing the human afamin gene and performing large-scale human epidemiological studies. METHODS AND RESULTS:...
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