Article
A question-based approach to adopting pharmacogenetics to understand risk for clinical variability in pharmacokinetics in early drug development.
Clinical pharmacology and therapeutics - 1 Sept 2014
Evers R, Blanchard R L, Warner A W, Cutler D, Agrawal N G B, Shaw P M
Abstract excerpt
Understanding genetic variations that influence pharmacokinetics (PK) in humans is important for optimal clinical use of drugs. Guidances for making decisions on when to conduct pharmacogenetic research during drug development have been proposed by regulatory agencies, but their uniform adoption presents problems due to an inherent lack of flexibility. A questions-based approach (QBA) was developed to enable drug...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.