Article
Biochemical staging of the chronic hepatic lesions of Wilson disease.
Nagoya journal of medical science - 1 Feb 2014
Katano Yoshiaki, Hayashi Kazuhiko, Hattori Ai, Tatsumi Yasuaki, Ueyama Jun, Wakusawa Shinya, Yano Motoyoshi, Toyoda Hidenori, Kumada Takashi, Mizutani Naoki, Hayashi Hisao, Goto Hidemi
Abstract excerpt
BACKGROUND: Copper toxicity steadily affects the livers of patients with Wilson disease. However, the toxic effect of copper on serum aspartate and alanine aminotransferase levels remains to be clarified as a prerequisite for diagnostic tests. The clinical records of 33 cases were analyzed to clarify the natural history of Wilson disease. Phenotypes were simplified into hepatic, acute, and neurologic. The bio-low...
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