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Article

Can the TLR-4-mediated signaling pathway be "a key inflammatory promoter for sporadic TAA"?

Mediators of inflammation - 1 Jan 2014

Ruvolo Giovanni, Pisano Calogera, Candore Giuseppina, Lio Domenico, Palmeri Cesira, Maresi Emiliano, Balistreri Carmela R

Abstract excerpt

Thoracic aorta shows with advancing age various changes and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur as pathological entities responsible principally for the sporadic TAA onset. Little is known about their genetic, molecular, and cellular mechanisms. Recent evidence is proposing the strong role of a chronic immune/inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25120286
DOI: 10.1155/2014/349476
PMCID: PMC4120489

Genes

TLR4
ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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