Article
Unfixed endogenous retroviral insertions in the human population.
Journal of virology - 1 Sept 2014
Marchi Emanuele, Kanapin Alex, Magiorkinis Gkikas, Belshaw Robert
Abstract excerpt
UNLABELLED: One lineage of human endogenous retroviruses (HERVs), HERV-K(HML2), is upregulated in many cancers, some autoimmune/inflammatory diseases, and HIV-infected cells. Despite 3 decades of research, it is not known if these viruses play a causal role in disease, and there has been recent interest in whether they can be used as immunotherapy targets. Resolution of both these questions will be helped by an...
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