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Article

α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease.

Neuroscience letters - 19 Sept 2014

Altarescu Gheona, Ioscovich Daniel, Alcalay Roy N, Zimran Ari, Elstein Deborah

Abstract excerpt

Mutations in β-glucocerebrosidase, the genetic defect in Gaucher disease (GD), are an important susceptibility factor for Parkinson disease (PD). A PD effector is α-synuclein (SNCA) hypothesized to selectively interact with β-glucocerebrosidase under lysosomal conditions. SNCA polymorphism rs356219 may be associated with early-age-onset PD, common among patients with GD+PD. The objective of this study was to...

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Source

Identifiers

PMID: 25111979
DOI: 10.1016/j.neulet.2014.07.051

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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