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Two novel toxin variants revealed by whole-genome sequencing of 175 Clostridium botulinum type E strains.

Applied and environmental microbiology - 1 Oct 2014

Weedmark K A, Lambert D L, Mabon P, Hayden K L, Urfano C J, Leclair D, Van Domselaar G, Austin J W, Corbett C R

Abstract excerpt

We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin (bont) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of...

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Identifiers

PMID: 25107978
DOI: 10.1128/AEM.01573-14
PMCID: PMC4178653

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