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Article

A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever

7 Aug 2014

Abstract excerpt

Mayaro virus (MAYV) is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient...

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Identifiers

PMID: 25101995
DOI: 10.1371/journal.pntd.0002969

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