Prioritizing candidate disease miRNAs by integrating phenotype associations of multiple diseases with matched miRNA and mRNA expression profiles.

Abstract excerpt

MicroRNAs (miRNAs) have been validated to show widespread disruption of function in many cancers. However, despite concerted efforts to develop prioritization approaches based on a priori knowledge of disease-associated miRNAs, uncovering oncogene or tumor-suppressor miRNAs remains a challenge. Here, based on the assumption that diverse diseases with phenotype associations show similar molecular mechanisms, we...

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