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Article

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology.

The Journal of cell biology - 4 Aug 2014

Hayes Polly, Varga Vladimir, Olego-Fernandez Sofia, Sunter Jack, Ginger Michael L, Gull Keith

Abstract excerpt

Individual eukaryotic microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a defined size, shape, and form yet transition through life cycle stages, each having a distinct morphology. In questioning the structural processes involved in these transitions, we have identified a large calpain-like protein that contains numerous GM6 repeats (ClpGM6) involved in determining T. brucei cell shape, size,...

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Identifiers

PMID: 25092656
DOI: 10.1083/jcb.201312067
PMCID: PMC4121973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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