Article
Genotyping of α-thalassemias by the colorimetric nanogold probes.
Clinica chimica acta; international journal of clinical chemistry - 1 Nov 2014
Chomean Sirinart, Wangmaung Nantawan, Sritongkham Pornpimol, Promptmas Chamras, Ittarat Wanida
Abstract excerpt
BACKGROUND: The novel colorimetric nanogold probe was created to genotype subgroups of the mostly found α-thalassemias. They are α-thalassemia 1 (SEA and THAI deletion) and α-thalassemia 2 (3.7-kb and 4.2-kb deletion). METHODS: The genotyping was performed by two-steps hybridizations. First step was hybridization of target DNA with the nanogold mixed probes of either α-thalassemia 1 or α-thalassemia 2. No...
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