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Article

Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats.

G3 (Bethesda, Md.) - 1 Aug 2014

David Victor A, Menotti-Raymond Marilyn, Wallace Andrea Coots, Roelke Melody, Kehler James, Leighty Robert, Eizirik Eduardo, Hannah Steven S, Nelson George, Schäffer Alejandro A, Connelly Catherine J, O'Brien Stephen J, Ryugo David K

Abstract excerpt

The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation. We performed linkage analysis using a pedigree segregating White to identify KIT (Chr. B1) as the feline W locus. Segregation and sequence analysis of the KIT gene in two pedigrees (P1 and P2) revealed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25085922
DOI: 10.1534/g3.114.013425
PMCID: PMC4199695

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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