Article
Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.
Reproductive toxicology (Elmsford, N.Y.) - 1 Nov 2014
Brokken L J S, Lundberg P J, Spanò M, Manicardi G C, Pedersen H S, Struciński P, Góralczyk K, Zviezdai V, Jönsson B A G, Bonde J P, Toft G, Lundberg Giwercman Y, Giwercman A
Abstract excerpt
Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.