Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias.

Journal of human genetics - 1 Jul 2012

Qin Xian-Yang, Kojima Yoshiyuki, Mizuno Kentaro, Ueoka Katsuhiko, Massart Francesco, Spinelli Claudio, Zaha Hiroko, Okura Masahiro, Yoshinaga Jun, Yonemoto Junzo, Kohri Kenjiro, Hayashi Yutaro, Ogata Tsutomu, Sone Hideko

Abstract excerpt

We hypothesized that single-nucleotide polymorphisms (SNPs) of genes involved in environmental endocrine disruptors (EEDs) metabolism might influence the risk of male genital malformations. In this study, we explored for association between 384 SNPs in 15 genes (AHR, AHRR, ARNT, ARNT2, NR1I2, RXRA, RXRB, RXRG, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP3A4, CYP17A1 and CYP19A1) and risk of cryptorchidism (CO) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cryptorchidism

Share to Cytochrome P-450 CYP1A2

Share to Endocrine Disruptors

Share to Estrogen Receptor alpha

Share to Hypospadias

Share to Steroid 17-alpha-Hydroxylase

Source

Identifiers

PMID: 22648180
DOI: 10.1038/jhg.2012.48

Genes

ARNT2
AHR
AHRR
ARNT
EED
RXRA
RXRB
RXRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias.PMID 22648180Read ↗

Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in malesSemantic proximity Read ↗

Molecular epidemiology of hypospadias: review of genetic and environmental risk factors.Semantic proximity Read ↗

Hypospadias and variants in genes related to sex hormone biosynthesis and metabolism.Semantic proximity Read ↗

Integrative causal and single-cell analyses reveal genes responsive to endocrine disruptors driving human male infertilitySemantic proximity Read ↗

Genetic, Maternal, and Environmental Risk Factors for Cryptorchidism: An UpdateSemantic proximity Read ↗

Gene-environment interactions in male reproductive health: special reference to the aryl hydrocarbon receptor signaling pathway.Semantic proximity Read ↗

Genome-wide association analyses identify variants in developmental genes associated with hypospadias.Semantic proximity Read ↗

Parental occupational exposure to endocrine disrupting chemicals and male genital malformations: A study in the danish national birth cohort studySemantic proximity Read ↗

Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal PromoterSemantic proximity Read ↗

Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias.Semantic proximity Read ↗

Endocrine Disruptors, Genital Development, and HypospadiasSemantic proximity Read ↗

Hypospadias: interactions between environment and genetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.