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Article

Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues.

The Journal of clinical endocrinology and metabolism - 1 Oct 2014

van der Klaauw Agatha A, von dem Hagen Elisabeth A H, Keogh Julia M, Henning Elana, O'Rahilly Stephen, Lawrence Andrew D, Calder Andrew J, Farooqi I Sadaf

Abstract excerpt

CONTEXT: Mutations in the melanocortin-4 receptor (MC4R) represent the commonest genetic form of obesity and are associated with hyperphagia. OBJECTIVE: The aim of this study was to investigate whether melanocortin signaling modulates anticipatory food reward by studying the brain activation response to food cues in individuals with MC4R mutations. Design/Setting/Participants/Main Outcome Measure: We used...

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Source

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Identifiers

PMID: 25062455
DOI: 10.1210/jc.2014-1651
PMCID: PMC4258603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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