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Article

Breach of tolerance: primary biliary cirrhosis.

Seminars in liver disease - 1 Aug 2014

Wang Lifeng, Wang Fu-Sheng, Chang Christopher, Gershwin M Eric

Abstract excerpt

In primary biliary cirrhosis (PBC), the breach of tolerance that leads to active disease involves a disruption in several layers of control, including central tolerance, peripheral anergy, a "liver tolerance effect," and the action of T regulatory cells and their related cytokines. Each of these control mechanisms plays a role in preventing an immune response against self, but all of them act in concert to...

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Identifiers

PMID: 25057953
DOI: 10.1055/s-0034-1383729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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