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Article

Skin equivalent tensional force alters keloid fibroblast behavior and phenotype

21 Jul 2014

Abstract excerpt

Skin tension may influence keloid scar behavior, development, and spreading, e.g., butterfly-shaped keloid disease in the sternum. Here, we developed a three-dimensional (3D) in vitro model to mimic in vivo tension and evaluate keloid fibroblast (KF) behavior and extracellular matrix synthesis under tension. In vivo skin tension measured in volunteers (n = 4) using 3D image photogrammetry enabled prediction of...

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PMID: 25046655
DOI: 10.1111/wrr.12215

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