Quantification of rare <i><scp>NPM</scp>1</i> mutation subtypes by digital <scp>PCR</scp>

Abstract excerpt

Nucleophosmin (NPM1) mutations (NPM1mut) are found in 45–55% of patients with normal karyotype acute myeloid leukaemia and are favourable in the presence of wildtype FLT3 (Falini et al, 2005; Schnittger et al, 2005). More than 70% of NPM1mut are type A; 25% have rare subtypes (Alpermann et al, 2013). Quantitative real-time polymerase chain reaction (RQ-PCR) assays targeting NPM1mut are available for monitoring...

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