Article
Measurement of absolute copy number variation reveals association with essential hypertension.
BMC medical genomics - 15 Jul 2014
Marques Francine Z, Prestes Priscilla R, Pinheiro Leonardo B, Scurrah Katrina, Emslie Kerry R, Tomaszewski Maciej, Harrap Stephen B, Charchar Fadi J
Abstract excerpt
BACKGROUND: The role of copy number variation (CNV) has been poorly explored in essential hypertension in part due to technical difficulties in accurately assessing absolute numbers of DNA copies. Droplet digital PCR (ddPCR) provides a powerful new approach to CNV quantitation. The aim of our study was to investigate whether CNVs located in regions previously associated with blood pressure (BP) variation in...
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