Article
Novel APP K724M mutation causes Chinese early-onset familial Alzheimer's disease and increases amyloid-β42 to amyloid-β40 ratio.
Neurobiology of aging - 1 Nov 2014
Peng Xiang-Lei, Hou Lei, Xu Shao-Hua, Hua Ying, Zhou Shu-Jie, Zhang Ying, Zheng Yan-Peng, Fu Yuan-Hui, Xu Qing, Zhang Li-Shu, Wang Jun, Guan Xiao-Ting, He Jin-Sheng
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorder among the elderly individuals. Although there are several million cases of AD estimated in China with the most population in the world, no Chinese early-onset familial AD caused by new APP gene mutation has ever been reported. Here, we first described a Chinese family with early-onset AD that was inherited in autosomal dominant manner, and the...
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