Androgen receptor polymorphism-dependent variation in prostate-specific antigen concentrations of European men.

doi:10.1158/1055-9965.EPI-14-0376

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Androgen receptor polymorphism-dependent variation in prostate-specific antigen concentrations of European men.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2014

Bentmar Holgersson Magdalena, Giwercman Aleksander, Bjartell Anders, Wu Frederick C W, Huhtaniemi Ilpo T, O'Neill Terence W, Pendleton Neil, Vanderschueren Dirk, Lean Michael E J, Han Thang S, Finn Joseph D, Kula Krzysztof, Forti Gianni, Casanueva Felipe F, Bartfai György, Punab Margus, Lundberg Giwercman Yvonne

Abstract excerpt

BACKGROUND: Androgens acting via the androgen receptor (AR) stimulate production of PSA, which is a clinical marker of prostate cancer. Because genetic variants in the AR may have a significant impact on the risk of being diagnosed with prostate cancer, the aim was to investigate whether AR variants were associated with the risk of having PSA above clinically used cutoff thresholds of 3 or 4 ng/mL in men without...

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PMID: 25012998
DOI: 10.1158/1055-9965.EPI-14-0376

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