Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma.

doi:10.1007/s00401-014-1315-x

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Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma.

Acta neuropathologica - 1 Oct 2014

Wiestler Benedikt, Capper David, Sill Martin, Jones David T W, Hovestadt Volker, Sturm Dominik, Koelsche Christian, Bertoni Anna, Schweizer Leonille, Korshunov Andrey, Weiß Elisa K, Schliesser Maximilian G, Radbruch Alexander, Herold-Mende Christel, Roth Patrick, Unterberg Andreas, Hartmann Christian, Pietsch Torsten, Reifenberger Guido, Lichter Peter, Radlwimmer Bernhard, Platten Michael, Pfister Stefan M, von Deimling Andreas, Weller Michael, Wick Wolfgang

Abstract excerpt

The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses is superior to histopathology for reflecting distinct biological groups, predicting outcomes and guiding therapy decisions has yet to be determined. Epigenome-wide DNA methylation analysis, using a platform which also allows the detection...

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PMID: 25008768
DOI: 10.1007/s00401-014-1315-x

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