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Article

Peroxisome Proliferator-Activated Receptor-γ C190S Mutation Causes Partial Lipodystrophy

14 Mar 2007

Abstract excerpt

CONTEXT: Mutations in PPARG are associated with insulin resistance and familial partial lipodystrophy, a disease characterized by altered distribution of sc fat and symptoms of the metabolic syndrome. The encoded protein, peroxisome proliferator-activated receptor (PPAR)-gamma, plays a pivotal role in regulating lipid and glucose metabolism, the differentiation of adipocytes, and other cellular regulatory...

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Identifiers

PMID: 17356052
DOI: 10.1210/jc.2005-2624

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