[Amyloidgenesis in prion disease].

Abstract excerpt

Prion diseases, also known as transmissible spongiform encephalopathies, are defined as fatal, neurodegenerative, and transmissible disorders that affect both humans and other mammalian species. The central pathogenic mechanism in prion diseases is the conformational conversion of the normal prion protein, PrPC into the pathogenic prion protein, PrPSc. PrPSc, which is rich in β-sheet structure, is resistant to...

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