Article
Whole genome and exome sequencing of monozygotic twins discordant for Crohn's disease.
BMC genomics - 5 Jul 2014
Petersen Britt-Sabina, Spehlmann Martina E, Raedler Andreas, Stade Björn, Thomsen Ingo, Rabionet Raquel, Rosenstiel Philip, Schreiber Stefan, Franke Andre
Abstract excerpt
BACKGROUND: Crohn's disease (CD) is an inflammatory bowel disease caused by genetic and environmental factors. More than 160 susceptibility loci have been identified for IBD, yet a large part of the genetic variance remains unexplained. Recent studies have demonstrated genetic differences between...
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