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Article

Assessment of folate receptor-α and epidermal growth factor receptor expression in pemetrexed-treated non-small-cell lung cancer patients.

Clinical lung cancer - 1 Sept 2014

Christoph Daniel C, Reyna-Asuncion Bernadette, Hassan Biftu, Tran Cindy, Maltzman Julia D, O'Shannessy Daniel J, Gauler Thomas C, Wohlschlaeger Jeremias, Schuler Martin, Eberhardt Wilfried E, Hirsch Fred R

Abstract excerpt

INTRODUCTION: Folate receptor-α regulates cellular uptake of folates and antifolates (eg, pemetrexed) and is frequently expressed in pulmonary adenocarcinoma. EGFR is an established therapeutic target in NSCLC. Therapies targeting FRA or EGFR are available. The association between FRA and EGFR expression in advanced NSCLC has not been explored. Combining therapeutic FRA antibodies with an EGFR inhibitor might be...

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Identifiers

PMID: 24993594
DOI: 10.1016/j.cllc.2014.05.002

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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