Article
Associations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases.
Clinical and experimental immunology - 1 Nov 2014
Inoue Y, Watanabe M, Inoue N, Kagawa T, Shibutani S, Otsu H, Saeki M, Takuse Y, Hidaka Y, Iwatani Y
Abstract excerpt
It is important to search the biomarker to predict the development and prognosis of autoimmune thyroid diseases (AITDs) such as Hashimoto's disease (HD) and Graves' disease (GD). MicroRNA (miR) bind directly to the 3' untranslated region of specific target mRNAs to suppress the expression of proteins, promote the degradation of target mRNAs and regulate immune response. miR-125a is known to be a negative...
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