Article
Evaluation of (99m)Tc-probestin SPECT as a novel technique for noninvasive imaging of kidney aminopeptidase N expression.
Molecular pharmaceutics - 4 Aug 2014
Pathuri Gopal, Madka Venkateshwar, Hedrick Andria F, Lightfoot Stanley A, Awasthi Vibhudutta, Cowley Benjamin D, Rao Chinthalapally V, Gali Hariprasad
Abstract excerpt
Aminopeptidase N (APN; CD13; EC 3.4.11.2) is a zinc-dependent membrane-bound exopeptidase that catalyzes the removal of N-terminal amino acids from peptides. APN is known to be highly expressed on renal cortical proximal tubules. APN expression levels are markedly decreased under the influence of nephrotoxins and in the tumor regions of renal cancers. Thus, molecular imaging of kidney APN expression could provide...
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