Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs.

Abstract excerpt

The list of human disordered associated with cilia dysfunction, the ciliopathies, continues to highlight the importance of understanding the many roles of the long overlooked primary cilium. Much of the insights into the clinical importance of the cilium have come from analyses in model organisms, especially the mouse. However, the early embryonic lethality and severe developmental defects associated with cilia...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Culture Techniques
• Share to Cilia
• Share to Embryo, Mammalian