Article
Vascular endothelial growth factor-A is associated with chronic mountain sickness in the Andean population.
High altitude medicine & biology - 1 Jun 2014
Espinoza Jose R, Alvarez Giancarlo, León-Velarde Fabiola, Preciado Hugo F Ju, Macarlupu Jose-Luis, Rivera-Ch Maria, Rodriguez Jorge, Favier Judith, Gimenez-Roqueplo Anne-Paule, Richalet Jean-Paul
Abstract excerpt
A study of chronic mountain sickness (CMS) with a candidate gene--vascular endothelial growth factor A (VEGFA)--was carried out in a Peruvian population living at high altitude in Cerro de Pasco (4380 m). The study was performed by genotyping of 11 tag SNPs encompassing 2.2 kb of region of VEGFA gene in patients with a diagnosis of CMS (n = 131; 49.1 ± 12.7 years old) and unrelated healthy controls (n = 84; 47.2...
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