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Article

Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats.

PLoS genetics - 1 Jun 2014

Brahmachary Manisha, Guilmatre Audrey, Quilez Javier, Hasson Dan, Borel Christelle, Warburton Peter, Sharp Andrew J

Abstract excerpt

Tandem repeats are common in eukaryotic genomes, but due to difficulties in assaying them remain poorly studied. Here, we demonstrate the utility of Nanostring technology as a targeted approach to perform accurate measurement of tandem repeats even at extremely high copy number, and apply this technology to genotype 165 HapMap samples from three different populations and five species of non-human primates. We...

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Identifiers

PMID: 24945355
DOI: 10.1371/journal.pgen.1004418
PMCID: PMC4063668

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Source receipt: pubmed, retrieved 7 Sept 2026.

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