Article
Mechanisms of pyrethroid resistance in the dengue mosquito vector, Aedes aegypti: target site insensitivity, penetration, and metabolism.
PLoS neglected tropical diseases - 1 Jun 2014
Kasai Shinji, Komagata Osamu, Itokawa Kentaro, Shono Toshio, Ng Lee Ching, Kobayashi Mutsuo, Tomita Takashi
Abstract excerpt
Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following selection of the adults. Prior to the selections, the frequencies of V1016G and F1534C mutations in...
Topics
- Aedes
- Alleles
- Animals
- Cytochrome P-450 Enzyme System
- Female
- Gene Dosage
- Gene Knockdown Techniques
- Genetic Association Studies
- Genotype
- Inactivation, Metabolic