Article
Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes.
American journal of respiratory and critical care medicine - 1 Aug 2014
Mayer-Hamblett Nicole, Rosenfeld Margaret, Gibson Ronald L, Ramsey Bonnie W, Kulasekara Hemantha D, Retsch-Bogart George Z, Morgan Wayne, Wolter Daniel J, Pope Christopher E, Houston Laura S, Kulasekara Bridget R, Khan Umer, Burns Jane L, Miller Samuel I, Hoffman Lucas R
Abstract excerpt
RATIONALE: Pseudomonas aeruginosa undergoes phenotypic changes during cystic fibrosis (CF) lung infection. Although mucoidy is traditionally associated with transition to chronic infection, we hypothesized that additional in vitro phenotypes correlate with this transition and contribute to disease. OBJECTIVES: To characterize the relationships between in vitro P. aeruginosa phenotypes, infection stage, and...
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