Article
An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme.
Molecular microbiology - 1 Jul 2014
Romagnoli G, Verhoeven M D, Mans R, Fleury Rey Y, Bel-Rhlid R, van den Broek M, Seifar R Maleki, Ten Pierick A, Thompson M, Müller V, Wahl S A, Pronk J T, Daran J M
Abstract excerpt
Most available knowledge on fungal arginine metabolism is derived from studies on Saccharomyces cerevisiae, in which arginine catabolism is initiated by releasing urea via the arginase reaction. Orthologues of the S. cerevisiae genes encoding the first three enzymes in the arginase pathway were cloned from Kluyveromyces lactis and shown to functionally complement the corresponding deletion in S. cerevisiae....
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