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Article

Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription.

Human molecular genetics - 1 Nov 2014

Neben Cynthia L, Idoni Brian, Salva Joanna E, Tuzon Creighton T, Rice Judd C, Krakow Deborah, Merrill Amy E

Abstract excerpt

Fibroblast growth factor receptor 2 (FGFR2) promotes osteoprogenitor proliferation and differentiation during bone development, yet how the receptor elicits these distinct cellular responses remains unclear. Analysis of the FGFR2-skeletal disorder bent bone dysplasia syndrome (BBDS) demonstrates...

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Share to Acrocephalosyndactylia
Share to Core Binding Factor Alpha 1 Subunit
Share to DNA, Ribosomal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 2

Share to MAP Kinase Signaling System

Share to Osteoblasts

Share to Receptor, Fibroblast Growth Factor, Type 2

Share to Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 24908667
DOI: 10.1093/hmg/ddu282
PMCID: PMC4189901

Genes

FGFR2
FGF2
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24908667-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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