Article
Analysis of putative inhibitors of anthelmintic resistance mechanisms in cattle gastrointestinal nematodes.
International journal for parasitology - 1 Aug 2014
AlGusbi Salha, Krücken Jürgen, Ramünke Sabrina, von Samson-Himmelstjerna Georg, Demeler Janina
Abstract excerpt
Effects of the cytochrome P450 inhibitor piperonyl butoxide and the P-glycoprotein inhibitor verapamil on the efficacy of ivermectin and thiabendazole were studied in vitro in susceptible and resistant isolates of the cattle parasitic nematodes Cooperia oncophora and Ostertagia ostertagi. The effects of combined use of drug and piperonyl butoxide/verapamil, respectively, were investigated in the Egg Hatch Assay,...
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