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Article

Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2003

Jinno Hideto, Saeki Mayumi, Saito Yoshiro, Tanaka-Kagawa Toshiko, Hanioka Nobumitsu, Sai Kimie, Kaniwa Nahoko, Ando Masanori, Shirao Kuniaki, Minami Hironobu, Ohtsu Atsushi, Yoshida Teruhiko, Saijo Nagahiro, Ozawa Shogo, Sawada Jun-ichi

Abstract excerpt

SN-38 (7-ethyl-10-hydroxycamptothecin), an active metabolite of the antitumor prodrug irinotecan, is conjugated and detoxified to SN-38 10-O-beta-d-glucuronide by hepatic UDP-glucuronosyltransferase (UGT) 1A1. Recent studies have revealed that other UGT1A isoforms, UGT1A7 and UGT1A9, also partici...

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Identifiers

PMID: 12730278
DOI: 10.1124/jpet.103.051250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12730278-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.PMID 12730278Read ↗

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