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Article

The functional polymorphism rs73598374:G>A (p.Asp8Asn) of the ADA gene is associated with telomerase activity and leukocyte telomere length.

European journal of human genetics : EJHG - 1 Feb 2015

Concetti Fabio, Carpi Francesco M, Nabissi Massimo, Picciolini Matteo, Santoni Giorgio, Napolioni Valerio

Abstract excerpt

Recent evidence demonstrated a relevant role of adenosine deaminase (ADA) in replicative senescence of T cells through its capacity to modulate telomerase activity (TA). Herein, we tested the impact of the functional polymorphism ADA rs73598374:G>A (c.22G>A, p.Asp8Asn) on telomere biology, by measuring TA and leukocyte telomere length (LTL) in healthy subjects selected according to rs73598374 genotype....

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Topics

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Share to Adenosine Deaminase
Share to Aged
Share to Aged, 80 and over
Share to ADA gene
Share to Leukocytes
Share to Polymorphism, Single Nucleotide
Share to Telomerase
Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 24896148
DOI: 10.1038/ejhg.2014.102
PMCID: PMC4297891

Genes

ADA

Variants

rs73598374
rs73598374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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