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Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells

3 Jun 2014

Abstract excerpt

BACKGROUND: Fatty acid synthase (FAS) has been proven over-expressed in human breast cancer cells and consequently, has been recognized as a target for breast cancer treatment. Alpha-mangostin, a natural xanthone found in mangosteen pericarp, has a variety of biological activities, including anti-cancer effect. In our previous study, alpha-mangostin had been found both fast-binding and slow-binding inhibitions to...

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PMID: 24894151
DOI: 10.1186/1476-4598-13-138

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