Article
A novel SNP associated with nighttime pulse pressure in young-onset hypertension patients could be a genetic prognostic factor for cardiovascular events in a general cohort in Taiwan.
PloS one - 1 Jan 2014
Leu Hsin-Bang, Chung Chia-Min, Lin Shing-Jong, Lu Tse-Min, Yang Hsin-Chou, Ho Hung-Yun, Ting Chih-Tai, Lin Tsung-Hsien, Sheu Sheng-Hsiung, Tsai Wei-Chuan, Chen Jyh-Hong, Yin Wei-Hsian, Chiu Ting-Yu, Chen Chin-Iuan, Pan Wen-Harn, Chen Jaw-Wen
Abstract excerpt
BACKGROUND: Pulse pressure (PP) is a risk factor for cardiovascular disease. It has been reported that ambulatory blood pressure (BP) and nighttime BP parameters are heritable traits. However, the genetic association of pulse pressure and its clinical impact remain undetermined. METHOD AND RESULTS: We conducted a genome-wide association study of PP using ambulatory BP monitoring in young-onset hypertensive...
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