[The molecular mechanism between interstitial fluid pressure and malignant phenotype of salivary adenoid cystic carcinoma].

Abstract excerpt

OBJECTIVE: To explore the effects of stress imposed on adenoid cystic carcinoma (ACC), therefore to clarify the molecular basis and mechanism of ACC's malignant phenotype under the elevated tumor interstitial fluid pressure. METHODS: ACC cells were cultured under pressure (103.74 kPa), and were divided into four groups (3 h group, 6 h group, 12 h group, 24 h group) according the pressure time. Untreated ACC2 was...

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