Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.

doi:10.1073/pnas.1320769111

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Article

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014

Dave Bhuvanesh, Granados-Principal Sergio, Zhu Rui, Benz Stephen, Rabizadeh Shahrooz, Soon-Shiong Patrick, Yu Ke-Da, Shao Zhimin, Li Xiaoxian, Gilcrease Michael, Lai Zhao, Chen Yidong, Huang Tim H-M, Shen Haifa, Liu Xuewu, Ferrari Mauro, Zhan Ming, Wong Stephen T C, Kumaraswami Muthiah, Mittal Vivek, Chen Xi, Gross Steven S, Chang Jenny C

Abstract excerpt

We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) and myeloid leukemia factor 2 (MLF2) as the top candidates that affect BCSC self-renewal. Knockdown of RPL39 and MLF2 by specific siRNA nanoparticles in patient-derived and human cancer xenografts reduced tumor volume and lung metastases...

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Identifiers

PMID: 24876273
DOI: 10.1073/pnas.1320769111
PMCID: PMC4066479

Genes

MLF2
RPL39

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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