Article
Impact of the IL-18 gene polymorphism in response to antiviral therapy in chronic HCV genotype 4 patients.
Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2000
Mandour Mohamed, Nemr Nader, Kishk Rania, Ahmed Eman
Abstract excerpt
INTRODUCTION: Interleukin (IL)-18 is a well-known major proinflammatory cytokine with broad biological effects. The major immunomodulatory functions of IL-18 include enhancing T cell and natural killer cell cytotoxicity. Serum levels of this cytokine were shown to increase in chronic hepatitis C patients compared to non-infected healthy people. An association between IL-18 gene promoter polymorphisms and...
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