Article
Baicalein ameliorates inflammatory-related apoptotic and catabolic phenotypes in human chondrocytes.
International immunopharmacology - 1 Aug 2014
Zhang Xiaodong, Zhu Yingjie, Chen Xiantao, Zhang Yun, Zhang Ying, Jia Yudong, Wang Huichao, Liu Youwen, Xiao Lianbo
Abstract excerpt
Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide. In OA, pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α can trigger the caspase cascade to promote apoptosis and activate NF-κB to induce catabolic factors in chondrocytes. Here, the...
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