Article
Directed differentiation of human induced pluripotent stem cells toward bone and cartilage: in vitro versus in vivo assays.
Stem cells translational medicine - 1 Jul 2014
Phillips Matthew D, Kuznetsov Sergei A, Cherman Natasha, Park Kyeyoon, Chen Kevin G, McClendon Britney N, Hamilton Rebecca S, McKay Ronald D G, Chenoweth Josh G, Mallon Barbara S, Robey Pamela G
Abstract excerpt
The ability to differentiate induced pluripotent stem cells (iPSCs) into committed skeletal progenitors could allow for an unlimited autologous supply of such cells for therapeutic uses; therefore, we attempted to create novel bone-forming cells from human iPSCs using lines from two distinct tissue sources and methods of differentiation that we previously devised for osteogenic differentiation of human embryonic...
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