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Article

Peptidoglycan recognition protein genes and risk of Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2014

Goldman Samuel M, Kamel Freya, Ross G Webster, Jewell Sarah A, Marras Connie, Hoppin Jane A, Umbach David M, Bhudhikanok Grace S, Meng Cheryl, Korell Monica, Comyns Kathleen, Hauser Robert A, Jankovic Joseph, Factor Stewart A, Bressman Susan, Lyons Kelly E, Sandler Dale P, Langston J William, Tanner Caroline M

Abstract excerpt

Increased gut permeability, inflammation, and colonic α-synuclein pathology are present in early Parkinson's disease (PD) and have been proposed to contribute to PD pathogenesis. Peptidoglycan is a structural component of the bacterial cell wall. Peptidoglycan recognition proteins (PGRPs) maintain healthy gut microbial flora by regulating the immune response to both commensal and harmful bacteria. We tested the...

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Identifiers

PMID: 24838182
DOI: 10.1002/mds.25895
PMCID: PMC4777298

Genes

PGLYRP4
PGLYRP2
PGLYRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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