Article
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2014
Feldman Darren R, Iyer Gopa, Van Alstine Lindsay, Patil Sujata, Al-Ahmadie Hikmat, Reuter Victor E, Bosl George J, Chaganti Raju S, Solit David B
Abstract excerpt
PURPOSE: A previous study noted frequent B-RAF mutations among European patients with cisplatin-resistant but not cisplatin-sensitive germ cell tumors (GCT). We sought to validate this finding by assessing for these mutations among patients with GCT at our center. EXPERIMENTAL DESIGN: Adolescent and adult patients with GCT who received cisplatin-based chemotherapy and had tumor tissue available were eligible for...
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