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Preeclampsia and Angiogenic Imbalance

16 Oct 2007

Abstract excerpt

Preeclampsia is a systemic syndrome of pregnancy that originates in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of preeclampsia was largely unknown, but recent work suggests a key role for altered expression of placental antiangiogenic factors. Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased in the maternal...

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PMID: 17937587
DOI: 10.1146/annurev.med.59.110106.214058

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