Double heterozygotes among breast cancer patients analyzed for BRCA1, CHEK2, ATM, NBN/NBS1, and BLM germ-line mutations.

doi:10.1007/s10549-014-2971-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Double heterozygotes among breast cancer patients analyzed for BRCA1, CHEK2, ATM, NBN/NBS1, and BLM germ-line mutations.

Breast cancer research and treatment - 1 Jun 2014

Sokolenko Anna P, Bogdanova Natalia, Kluzniak Wojciech, Preobrazhenskaya Elena V, Kuligina Ekatherina S, Iyevleva Aglaya G, Aleksakhina Svetlana N, Mitiushkina Natalia V, Gorodnova Tatiana V, Bessonov Alexandr A, Togo Alexandr V, Lubiński Jan, Cybulski Cezary, Jakubowska Anna, Dörk Thilo, Imyanitov Evgeny N

Abstract excerpt

17 double heterozygous (DH) breast cancer (BC) patients were identified upon the analysis of 5,391 affected women for recurrent Slavic mutations in BRCA1, CHEK2, NBN/NBS1, ATM, and BLM genes. Double heterozygosity was found for BRCA1 and BLM (4 patients), BRCA1 and CHEK2 (4 patients), CHEK2 and NBS1 (3 patients), BRCA1 and ATM (2 patients), CHEK2 and BLM (2 patients), CHEK2 and ATM (1 patient), and NBS1 and BLM...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 2

Share to Founder Effect

Share to Loss of Heterozygosity

Share to Poland

Share to RecQ Helicases

Share to Republic of Belarus

Share to Russia

Source

Open in PubMed

Identifiers

PMID: 24800916
DOI: 10.1007/s10549-014-2971-1

Genes

CHEK2
BRCA1
BLM
ATM
NBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Double heterozygotes among breast cancer patients analyzed for BRCA1, CHEK2, ATM, NBN/NBS1, and BLM germ-line mutations.PMID 24800916Read ↗

Development of breast tumors in CHEK2, NBN/NBS1 and BLM mutation carriers does not commonly involve somatic inactivation of the wild-type allele.Semantic proximity Read ↗

Double Heterozygosity for Germline Mutations in Chinese Breast Cancer PatientsSemantic proximity Read ↗

Spectrum of double heterozygosity in individuals diagnosed with hereditary breast and ovarian cancer.Semantic proximity Read ↗

Gene panel testing of 5589 BRCA1/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer.Semantic proximity Read ↗

Clinicopathologic Profile of Breast Cancer in Germline ATM and CHEK2 Mutation Carriers.Semantic proximity Read ↗

Concurrent germline BRCA1, BRCA2, and CHEK2 pathogenic variants in hereditary breast cancer: a case series.Semantic proximity Read ↗

Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management.Semantic proximity Read ↗

Double Heterozygosity for Rare Deleterious Variants in the BRCA1 and BRCA2 Genes in a Hungarian Patient with Breast Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.