Article
[Von Willebrand factor and Von Willebrand disease].
Nederlands tijdschrift voor geneeskunde - 1 Jan 2014
Verhezen Paul W M, Beckers Erik A M, Henskens Yvonne M C
Abstract excerpt
Von Willebrand factor (VWF) is a multimeric adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in the circulation. VWD is classified into three major subtypes, distinguished by a quantitative deficiency of VWF (type 1: partial deficiency; type 3: complete deficiency) or qualitative defects of VWF (type 2A, 2B, 2M and 2N). Its diagnosis is based on both clinical and laboratory...
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